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PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22
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DeCS
Descriptor
English
:
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Descriptor
Spanish
:
Proteína Tirosina Fosfatasa no Receptora Tipo 22
Descriptor
Portuguese
:
Proteína Tirosina Fosfatase não Receptora Tipo 22
Tree Number:
D08.811.277.352.650.775.300.930
D12.644.360.585.930
D12.776.476.564.930
Definition
English
:
A subtype of non-receptor
protein tyrosine phosphatases
that is characterized by the presence of an N-terminal
catalytic domain
and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in
LYMPHOCYTES
and plays a key
role
in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of
AUTOIMMUNE DISEASES.
History Note
English
:
2008(1999)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
52703
Unique Identifier:
D054596
Occurrence in VHL
:
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